Abstract Title:

LRa05 Ameliorate Hyperglycemia through a Regulating Glucagon-Mediated Signaling Pathway and Gut Microbiota in Type 2 Diabetic Mice.

Abstract Source:

J Agric Food Chem. 2021 Aug 11 ;69(31):8797-8806. Epub 2021 Aug 2. PMID: 34340304

Abstract Author(s):

Tao Wu, Yongli Zhang, Wen Li, Yunjiao Zhao, Hairong Long, Esther Mwizerwa Muhindo, Rui Liu, Wenjie Sui, Qian Li, Min Zhang

Article Affiliation:

Tao Wu


In this study, we aimed to explore the antidiabetic effects ofLRa05 on glucose metabolism and gut microbiota in type 2 diabetes mellitus (T2DM) mice. Our data indicated that the fasting blood glucose levels were reduced by 53.5% after treatment with LRa05 at a dose of 10CFU·day. Meanwhile, LRa05 attenuated insulin resistance, relieved hepatic oxidative stress, and alleviated metabolic lipopolysaccharide-related inflammation in T2DM mice. LRa05 promoted the expression of glucose transporter 2, while it inhibited the expression of glucagon receptor, glucose-6-phosphatase, cellular adenosine-3'-5'-cyclic monophosphate-dependent protein kinase, and phosphoenolpyruvate carboxykinase in diabetic mice. Meanwhile, LRa05 reshaped gut microbiota, resulting in increased short-chain fatty acid bacteria (and) and decreased proinflammatory bacteria (and). Thus, LRa05 may be used as a functional food supplement for modulating the disorder glucose metabolism and gut microbiota in T2DM.

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