Lactobacillus rhamnosus probio-M9 improves the quality of life in stressed adults by gut microbiota. - GreenMedInfo Summary

OBJECTIVE: To evaluate the effect of the probiotic,Probio-M9 (Probio-M9), on the quality of life in stressed adults.

METHODS: Twelve postgraduate student volunteers were recruited. Six volunteers received oral Probio-M9 for 21 days, while the remaining six received a placebo instead. Fecal samples were collected from the volunteers before and after the intervention. Metagenomic sequencing, nontargeted metabonomics, and quality-of-life follow-up questionnaires were used to evaluate the impact of Probio-M9 consumption on the gut microbiota and life quality of the volunteers.

RESULTS: Probio-M9 improved the psychological and physiological quality-of-life symptoms significantly in stressed adults (<0.05). The probiotic intervention was beneficial in increasing and maintaining the diversity of gut microbiota. The abundance ofandincreased in the probiotics group. The feature metabolites of pyridoxamine, dopamine, and 5-hydroxytryptamine (5-HT) were positively correlated withandlevels, which might be why the mental state of the volunteers in the probiotic group improved after taking Probio-M9.

CONCLUSIONS: We identified that oral Probio-M9 can regulate the stability of gut microbiota and affect the related beneficial metabolites, thereby affecting the quality of life (QoL) of stressed adults. Probio-M9 might improve the psychological and physiological quality of life in stressed adults via the gut-brain axis pathway. The causal relationship should be further explored in future studies.