Article Publish Status: FREE
Abstract Title:

WIKIM30 Ameliorates Atopic Dermatitis-Like Skin Lesions by Inducing Regulatory T Cells and Altering Gut Microbiota Structure in Mice.

Abstract Source:

Front Immunol. 2018 ;9:1905. Epub 2018 Aug 14. PMID: 30154801

Abstract Author(s):

Min-Sung Kwon, Seul Ki Lim, Ja-Young Jang, Jieun Lee, Hyo Kyeong Park, Namhee Kim, Misun Yun, Mi-Young Shin, Hee Eun Jo, Young Joon Oh, Seong Woon Roh, Hak-Jong Choi

Article Affiliation:

Min-Sung Kwon


WIKIM30 is a Gram-positive facultative anaerobic bacterium isolated from kimchi, a Korean fermented vegetable food. In this study, we found that WIKIM30 promoted regulatory T cell (Treg) differentiation by inducing dendritic cells with tolerogenic properties. The production of the T helper (Th) 2-associated cytokine interleukin (IL)-4 was decreased, but that of the Treg-associated cytokine IL-10 was increased in splenocytes from ovalbumin-sensitized mice treated with WIKIM30. We also investigated the inhibitory capacity of WIKIM30 on the development of 2,4-dinitrochlorobenzene-induced atopic dermatitis (AD), a Th2-dominant allergic disease in mice. Oral administration ofWIKIM30 significantly reduced AD-like skin lesions and serum immunoglobulin E and IL-4 levels while decreasing the number of CD4T cells and B cells and the levels of Th2 cytokines (IL-4, IL-5, and IL-13) in peripheral lymph nodes and enhancing Treg differentiation and IL-10 secretion in mesenteric lymph nodes. In addition, WIKIM30 modulated gut microbiome profiles that were altered in AD mice, which showed increases inandand a decrease inabundance. These changes were reversed by WIKIM30 treatment. Notably, the increase inwas highly correlated with Treg-related responses and may contribute to the alleviation of AD responses. Together, these results suggest that oral administration ofWIKIM30 modulates allergic Th2 responses enhancing Treg generation and increases the relative abundance of intestinal bacteria that are positively related to Treg generation, and therefore has therapeutic potential for the treatment of AD.

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