Abstract Title:

Modulation of innate and adaptive immunity by lactoferrin in human immunodeficiency virus (HIV)-infected, antiretroviral therapy-naïve children.

Abstract Source:

Int J Antimicrob Agents. 2007 Mar;29(3):353-5. Epub 2007 Feb 2. PMID: 17276659

Abstract Author(s):

Gian Vincenzo Zuccotti, Alessandra Vigano, Manuela Borelli, Marina Saresella, Vania Giacomet, Mario Clerici


Oral lactoferrin supplementation in human immunodeficiency virus (HIV)-infected, antiretroviral therapy-naïve children resulted in a skewing of T-lymphocytes towards more differentiated subpopulations. Phagocytosis (P=0.01) and killing (P=0.009), Toll-like receptor 2 expression (P=0.01) and the interleukin-12/interleukin-10 ratio (P=0.001) were also improved by lactoferrin. Lactoferrin supplementation results in immune modulation and could be useful in HIV infection.

Study Type : Human Study

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Sayer Ji
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