Article Publish Status: FREE
Abstract Title:

Lactoferrin mitigates ethanol-induced gastric ulcer via modulation of ROS/ICAM-1/Nrf2 signaling pathway in Wistar rats.

Abstract Source:

Iran J Basic Med Sci. 2022 Dec ;25(12):1522-1527. PMID: 36544526

Abstract Author(s):

Gihan F Asaad, Rasha E Mostafa

Article Affiliation:

Gihan F Asaad


OBJECTIVES: We aimed to investigate the gastroprotective effect of lactoferrin (LF; 100&300 mg/kg) in male Wistar ratsgastric ulcers induced by 96% ethanol.

MATERIALS AND METHODS: Rats were randomly allocated into 4 groups: control, ethanol, ethanol+LF100, and ethanol+LF300. LF100&300 were given 15 days before ulcer induction. At the end of the experiment, the gastric mucosa was examined macroscopically and microscopically.

RESULTS: The ethanol group showed damage and degeneration of the stomach mucosa in addition to elevation of oxidative and inflammatory biomarkers. LF showed explicit healing of the gastric mucosal damage. LF reduced gastric malondialdehyde (MDA), tumor necrosis factorα(TNF-α), interleukin-1β(IL-1β), myeloperoxidase (MPO), and intracellular adhesion molecule-1 (ICAM-1). On the other hand, LF elevated the depleted reduced glutathione (GSH) and Nuclear factor-erythroid factor 2 (Nrf2).

CONCLUSION: Our current study is the first to study the antiulcer effect of LF via its potential modulatory effects on the ROS/ICAM-1/Nrf2 signaling pathway. Moreover, we concluded that pretreatment with LF100&300 mitigated the ethanol-induced gastric ulcer via modulation of both oxidative stress and inflammatory responses.

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