Abstract Title:

Alternative therapies in antibiotic-resistant infection.

Abstract Source:

Scand J Rheumatol. 1991;20(4):294-302. PMID: 17357317

Abstract Author(s):

B Weber-Dabrowska, M Zimecki, M Kruzel, I Kochanowska, M Lusiak-Szelachowska

Article Affiliation:

Institute of Immunology and Experimental Therapy,e Polish Academy of Sciences, Wrocław, Poland.


Case report: A 24-year-old woman suffering from post-influenza otitis media infection was initially treated with several series of a steroid (Elocon) and a combination of steroids and antibiotics (Atecortin, Dicortineff) without significant medical benefit. The isolated bacterial strains were identified as Staphylococcus homis and Staphylococcus epidermidis. Specific phage therapy applied sequentially over a period of three weeks resulted only in a partial reduction in inflammation and limited improvement in overall health condition. Oral application of lactoferrin (LF; 50-mg daily oral doses for seven days with two-week intervals) led to a complete clearance of both bacterial strains and full recovery of the patient. The recovery was associated with increased myelopoiesis and a sustained elevation of serum endogenous LF. In conclusion, specific bacteriophage therapy combined with the administration of lactoferrin proved to be effective in the treatment of antibiotic-resistant external ear infection.

Study Type : Human: Case Report

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