Abstract Title:

Late-onset warfarin-induced skin necrosis: case report and review of the literature.

Abstract Source:

Am J Hematol. 1998 Mar;57(3):233-7. PMID: 9495376

Abstract Author(s):

D W Essex, S S Wynn, D K Jin

Article Affiliation:

Department of Internal Medicine, State University of New York, Health Science Center at Brooklyn, 11203, USA.


Warfarin-induced skin necrosis is a rare complication of therapy with warfarin or other coumarin derivatives. When it occurs it usually appears 3 to 6 days after initiation of therapy and almost always between days 1 and 10. We report a case of late-onset (16 days after initiation of therapy) warfarin-induced skin necrosis and review the literature on this rarely reported variant of warfarin-induced skin necrosis. The skin lesion in our patient was not associated with either deficiency of protein C or resistance to activated protein C.

Study Type : Human: Case Report
Additional Links
Problem Substances : Warfarin : CK(273) : AC(30)
Adverse Pharmacological Actions : Necrotic : CK(18) : AC(9)

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