Late-onset warfarin-induced skin necrosis has been reported. - GreenMedInfo Summary
Late-onset warfarin-induced skin necrosis: case report and review of the literature.
Am J Hematol. 1998 Mar;57(3):233-7. PMID: 9495376
Department of Internal Medicine, State University of New York, Health Science Center at Brooklyn, 11203, USA.
Warfarin-induced skin necrosis is a rare complication of therapy with warfarin or other coumarin derivatives. When it occurs it usually appears 3 to 6 days after initiation of therapy and almost always between days 1 and 10. We report a case of late-onset (16 days after initiation of therapy) warfarin-induced skin necrosis and review the literature on this rarely reported variant of warfarin-induced skin necrosis. The skin lesion in our patient was not associated with either deficiency of protein C or resistance to activated protein C.
