Article Publish Status: FREE
Abstract Title:

Antimicrobial Activity of New Materials Based on Lavender and Basil Essential Oils and Hydroxyapatite.

Abstract Source:

Nanomaterials (Basel). 2018 Apr 30 ;8(5). Epub 2018 Apr 30. PMID: 29710862

Abstract Author(s):

Daniela Predoi, Simona Liliana Iconaru, Nicolas Buton, Monica Luminita Badea, Luminita Marutescu

Article Affiliation:

Daniela Predoi


This study presents, for the first-time, the results of a study on the hydrodynamic diameter of essential oils (EOs) of basil and lavender in water, and solutions of EOs of basil (B) and lavender (L) and hydroxyapatite (HAp). The possible influence of basil and lavender EOs on the size of hydroxyapatite nanoparticles was analyzed by Scanning Electron Microscopy (SEM). We also investigated the in vitro antimicrobial activity of plant EOs and plant EOs hydroxyapatite respectively, against Gram-positive bacteria (methicillin-resistant1144 (MRSA 1144) and1426) and Gram-negative bacteria (ATCC 25922 andESBL 4493). From the autocorrelation function, obtained by Dynamic Light Scattering (DLS) measurements it was observed that basil yielded one peak at an average hydrodynamic diameter of 354.16 nm, while lavender yielded one peak at an average hydrodynamic diameter of 259.76 nm. In the case of HAp nanoparticles coated with basil (HApB) and lavender (HApL) essential oil, the aggregation was minimal. We found that the lavender EO exhibited a very good inhibitory growth activity (MIC values ranging from<0.1% forreference strain to 0.78% forstrains). The biological studies indicated that HapL material displayed an enhanced antimicrobial activity, indicating the potential use of HAp as vehicle for low concentrations of lavender EO with antibacterial properties. Flow cytometry analysis (FCM) allowed us to determine some of the potential mechanisms of the antimicrobial activities of EOs, suggesting that lavender EO was active againstby interfering with membrane potential, the membrane depolarization effect being increased by incorporation of the EOs into the microporous structure of HAp. These findings could contribute to the development of new antimicrobial agents that are urgently needed for combating the antibiotic resistance phenomena.

Study Type : In Vitro Study

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