Article Publish Status: FREE
Abstract Title:

Protective role ofhydro-ethanolic leaf extract in cisplatin induced nephrotoxicity in Rats.

Abstract Source:

Toxicol Rep. 2018 ;5:270-277. Epub 2018 Feb 3. PMID: 29487802

Abstract Author(s):

Rupal Purena, Rohit Seth, Renu Bhatt

Article Affiliation:

Rupal Purena


Nephrotoxicity is a major limiting factor in cisplatin treatment. In the present study hydro-ethanolic leaf extract ofwas investigated for its protective role in cisplatin induced nephrotoxicity. The experiment was designed for 14 days and male Wistar rats were divided into 9 groups (n = 5). Group 1 served as control (with no treatment), group 2 served as a vehicle control and received 0.9% NaCl intraperitoneally (i.p.) on 11th day of the treatment, group 3 received a single dose of cisplatin on 11th day (12 mg/kg body weight, i.p.), group 4-6 received leaf extract only (100 mg/kg, 200 mg/kg and 400 mg/kg body weight, respectively) throughout the treatment, group 7-9 received leaf extract (100 mg/kg, 200 mg/kg and 400 mg/kg body weight, respectively) throughout the treatment and single dose of cisplatin on the 11th day of the leaf extract treatment. At the end of the experiment (on 14th day) blood samples were collected from all the groups and were sacrificed to study renal functional parameters. Treatment with above doses ofleaf extract significantly (p ≤ 0.05) attenuates renal damage by decreasing serum creatinine and blood urea nitrogen (BUN), enhanced the activities of Catalase, SOD, GPx, GR and decreased the renal MDA level compared with the cisplatin treatment group. Furthermore the oral administration of Amla leaf extract improves histological damage and morphological changes in RBCs. Our results suggest that, leaf extract ofmay ameliorate renal damage caused by cisplatin.

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