Abstract Title:

Anti-inflammatory effect of lemon mucilage: in vivo and in vitro studies.

Abstract Source:

Immunopharmacol Immunotoxicol. 2005;27(4):661-70. PMID: 16435583

Abstract Author(s):

Enza Maria Galati, Antonia Cavallaro, Tommaso Ainis, Maria Marcella Tripodo, Irene Bonaccorsi, Giuseppe Contartese, Maria Fernanda Taviano, Vincenzo Fimiani


The mucilage extracted from a lemon juice centrifugation pulp was studied for its anti-inflammatory effect in rat. In vivo the lemon mucilage significantly inhibited carrageenan-induced edema in rat paw from 59% to 73.5% showing the highest effect at the third hour. In vitro, at the doses of 10(-8), 10(-6), 10(-4) or 10(-2) mg/mL the lemon mucilage stimulated the superoxide anion production in rat testing neutrophils in whole blood but inhibited it in FMLP stimulated cells at the dose of 10(-2) mg/mL. The neutrophils of rats receiving p.o. the lemon mucilage for 21 days showed a significant decrease of 45.5% in O2- generation after FMLP stimulation, and a not-significant increase after phorbol-12-myristate-13-acetate (PMA) or zymosan stimulation. Since the activity on zymosan- and PMA-induced O2- production was not significant, the inhibition exerted by FMLP in rat neutrophils occurred mainly through the blockade of phospholipase D.


Study Type : Animal Study

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