Abstract Title:

Anti-angiogenic and antiproliferative properties of the lichen substances (-)-usnic acid and vulpinic acid.

Abstract Source:

Z Naturforsch C. 2015 ;70(5-6):159-64. PMID: 26136299

Abstract Author(s):

Ayşe Tansu Koparal

Article Affiliation:

Ayşe Tansu Koparal


The anti-proliferative activities of the lichen substances (-)-usnic acid and vulpinic acid on the viability of HepG2 hepatocarcinoma cells, NS20Y neuroblastoma cells and HUVEC endothelial cells were studied by the MTT assay. The anti-angiogenic potential of the substances was determined by the endothelial tube formation assay. Both lichen substances exhibited strong anti-angiogenic activity and were more cytotoxic to the cancer cell lines than to the normal cell line, but vulpinic acid has more potential as an anti-angiogenic substance because of its low cytotoxicity and stronger anti-angiogenic activity on the HUVEC cell line.

Study Type : In Vitro Study

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