Abstract Title:

Lignan content of the flaxseed influences its biological effects in healthy men and women.

Abstract Source:

J Am Coll Nutr. 2013 Jun ;32(3):194-9. PMID: 23885993

Abstract Author(s):

Rogelio U Almario, Sidika E Karakas

Article Affiliation:

a Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism , University of California at Davis , Davis , California.


Objective: The omega-3 polyunsaturated fatty acid (n-3 PUFA) as well as lignan components of flaxseed (FLX) can have beneficial effects. In this 6-week-long, randomized, double-blinded, placebo-controlled study, we investigated the effects of FLX lignans on cardiovascular risk factors. Methods: Thirty-seven subjects (13 men and 24 women, age: 54± 7 years, body mass index [BMI]: 29.7 ± 1 kg/m(2)) consumed nutrition bars with similar macronutrient contents. The fatty acid composition and the lignan contents of the bars differed significantly. Two FLX bars both contained 3.0 g of alpha linolenic acid (ALA: 18:3 n-3) but different amountof lignans (0.15 g vs. 0.41 g). Results: High-lignan FLX decreased total cholesterol (C) by 12% (p = 0.044), LDL-C by 15% (p = 0.022), and oxidized (Ox)-LDL by 25% (p = 0.035). Regular FLX tended to increase Ox-LDL by 13% (p = 0.051). The difference between the effects of high-lignan vs. regular lignan FLX on Ox-LDL was highly significant (p = 0.004). Conclusion: High-lignan FLX has the unique property of decreasing Ox-LDL, which is an independent risk factor for cardiovascular disease.

Study Type : Human Study

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