Lignans found within Schisandra demonstrate anti-HIV virus activity. - GreenMedInfo Summary
Abstract Title:
Lignans with anti-HIV activity from Schisandra propinqua var. sinensis.
Abstract Source:
J Nat Prod. 2009 Jun;72(6):1133-41. PMID: 19413342
Abstract:
Fourteen new lignans, tiegusanins A-N (1-14), together with 13 known compounds were isolated from the aerial parts of Schisandra propinqua var. sinensis. The structures and absolute configurations of 1-13 were established using a combination of spectroscopic techniques. Compound 14 was obtained as a racemate. When evaluated for inhibitory activity against HIV-1, tiegusanin G (7) showed anti-HIV-1 activity with an EC(50) value of 7.9 microM and a therapeutic index (TI) of more than 25.
Article Published Date : Jun 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Schisandra : CK(192) : AC(77)
Diseases : HIV Infections : CK(1193) : AC(399)
Pharmacological Actions : Antiviral Agents : CK(3097) : AC(1704)
