Abstract Title:

Antiproliferative effects of dibenzocyclooctadiene lignans isolated from Schisandra chinensis in human cancer cells.

Abstract Source:

Bioorg Med Chem Lett. 2008 Jan 15;18(2):523-6. Epub 2007 Nov 28. PMID: 18063366

Abstract Author(s):

Hye-Young Min, Eun-Jung Park, Ji-Young Hong, You-Jin Kang, Sun-Jack Kim, Hwa-Jin Chung, Eun-Rhan Woo, Tran Manh Hung, Ui Jung Youn, Yeong Shik Kim, Sam Sik Kang, KiHwan Bae, Sang Kook Lee


Dibenzocyclooctadiene lignans isolated from Schisandra chinensis showed antiproliferative effects in various human cancer cells. The methoxy groups at C-3, C-4, C-3', and C-4', the hydroxyl group at C-8', and the stereo-configuration of the biphenyl ring and the angeloyl group might have influence on these activities. Additional studies indicate that one of mechanism of action of an active compound schizantherin C in A549 human lung cancer cells was related to the inhibition of cell cycle progression in G0/G1 phase.

Study Type : In Vitro Study
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