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Article Publish Status: FREE
Abstract Title:

Anti-Lung-Cancer Activity and Liposome-Based Delivery Systems ofβ-Elemene.

Abstract Source:

Evid Based Complement Alternat Med. 2012 ;2012:259523. Epub 2012 Nov 28. PMID: 23243436

Abstract Author(s):

Meiwan Chen, Jinming Zhang, Siqin Yu, Shengpeng Wang, Zaijun Zhang, Jianqiang Chen, Jian Xiao, Yitao Wang

Article Affiliation:

Meiwan Chen

Abstract:

In the past decade,β-elemene played an important role in enhancing the effects of many anticancer drugs and was widely used in the treatment of different kinds of malignancies and in reducing the side effects of chemotherapy. Further study showed that it is also a promising anti-lung cancer drug. However, the clinical application of β-elemene was limited by its hydrophobic property, poor stability, and low bioavailability. With the development of new excipients and novel technologies, plenty of novel formulations of β-elemene have improved dramatically, which provide a positive perspective in terms of clinical application for β-elemene. Liposome as a drug delivery system shows great advantages over traditional formulations for β-elemene. In this paper, we summarize the advanced progress being made in anti-lung cancer activity and the new liposomes delivery systems of β-elemene. This advancement is expected to improve the level of pharmacy research and provide a stronger scientific foundation for further study on β-elemene.

Study Type : Review

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