Article Publish Status: FREE
Abstract Title:

Local ice cryotherapy decreases synovial interleukin 6, interleukin 1β, vascular endothelial growth factor, prostaglandin-E2, and nuclear factor kappa B p65 in human knee arthritis: a controlled study.

Abstract Source:

Arthritis Res Ther. 2019 Jul 30 ;21(1):180. Epub 2019 Jul 30. PMID: 31362785

Abstract Author(s):

X Guillot, N Tordi, C Laheurte, L Pazart, C Prati, P Saas, D Wendling

Article Affiliation:

X Guillot


BACKGROUND: The aim of this study was to assess the anti-inflammatory effects of local cryotherapy in human non-septic knee arthritis.

METHODS: In the phase I of the study, patients were randomized to receive either ice (30 min; N = 16) or cold CO(2 min; N = 16) applied twice during 1 day at an 8-h interval on the arthritic knee. In phase II, 16 other ice-treated arthritic knees according to the same protocol were compared to the contralateral non-treated arthritic knees (N = 16). The synovial fluid was analyzed just before the first cold application, then 24 h later. IL-6, IL-1β, TNF-α, IL-17A, VEGF, NF-kB-p65 protein, and PG-E2 levels were measured in the synovial fluid and compared before/after the two cold applications.

RESULTS: Forty-seven patients were included (17 gouts, 11 calcium pyrophosphate deposition diseases, 13 rheumatoid arthritides, 6 spondyloarthritides). Local ice cryotherapy significantly reduced the IL-6, IL-1β, VEGF, NF-kB-p65, and PG-E2 synovial levels, especially in the microcrystal-induced arthritis subgroup, while only phosphorylated NF-kB-p65 significantly decreased in rheumatoid arthritis and spondyloarthritis patients. Cold COonly reduced the synovial VEGF levels. In the phase II of the study, the synovial PG-E2 was significantly reduced in ice-treated knees, while it significantly increased in the corresponding contralateral non-treated arthritic knees, with a significant inter-class effect size (mean difference - 1329 [- 2232; - 426] pg/mL; N = 12).

CONCLUSIONS: These results suggest that local ice cryotherapy reduces IL-6, IL-1β, and VEGF synovial protein levels, mainly in microcrystal-induced arthritis, and potentially through NF-kB and PG-E2-dependent mechanisms.

TRIAL REGISTRATION: Clinicaltrials.gov, NCT03850392-registered February 20, 2019-retrospectively registered.

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