Abstract Title:

Loneliness in healthy young adults predicts inflammatory responsiveness to a mild immune challenge in vivo.

Abstract Source:

Brain Behav Immun. 2019 Nov ;82:298-301. Epub 2019 Aug 30. PMID: 31476413

Abstract Author(s):

Leonie J T Balter, Jane E Raymond, Sarah Aldred, Mark T Drayson, Jet J C S Veldhuijzen van Zanten, Suzanne Higgs, Jos A Bosch

Article Affiliation:

Leonie J T Balter


The established link between loneliness and poor health outcomes may stem from aberrant inflammatory regulation. The present study tested whether loneliness predicted the inflammatory response to a standardised in vivo immune challenge. Using a within-subjects double blind placebo-controlled design, 40 healthy men (mean age = 25, SD = 5) received a Salmonella Typhi vaccination (0.025 mg; Typhim Vi, Sanofi Pasteur, UK) and placebo (saline) on two separate occasions. Loneliness was assessed using the R-UCLA loneliness scale. Regression analyses showed that those that reported feeling more lonely exhibited an elevated interleukin-6 response (β = 0.564, 95% confidence interval [0.003, 0.042], p < .05). This association withstood adjustment for potentially confounding variables, including age, sleep quality, socio-emotional factors, and health factors. The present findings are in line with evidence that loneliness may shift immune system responsivity, suggesting a potential biobehaviouralpathway linking loneliness to impaired health.

Study Type : Human Study
Additional Links
Adverse Pharmacological Actions : Immunosuppressive : CK(234) : AC(46)

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