Abstract Title:

Search forβ-Secretase Inhibitors from Natural Spices.

Abstract Source:

Nat Prod Commun. 2016 Apr ;11(4):507-10. PMID: 27396206

Abstract Author(s):

Shinichi Matsumura, Kazuya Murata, Yuri Yoshioka, Hideaki Matsuda

Article Affiliation:

Shinichi Matsumura


The growing number of Alzheimer's disease (AD) patients prompted us to seek effective natural resources for the prevention of AD. We focused on the inhibition ofβ-secretase, which is known to catalyze the production of senile plaque. Sixteen spices used in Asian countries were selected for the screening. Among the extracts tested, hexane extracts obtained from turmeric, cardamom, long pepper, cinnamon, Sichuan pepper, betel, white turmeric and aromatic ginger showed potent inhibitory activities. Their active principles were identified as sesquiterpenoids, monoterpenoids, fatty acid derivatives and phenylpropanoids using GC-MS analyses. The chemical structures and IC50 values of the compounds are disclosed. The results suggest that long-term consumption'of aromatic compounds from spices could be effective in the prevention of AD.

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