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Abstract Title:

Protective Effect of Coriander (L.) on High-Fructose and High-Salt Diet-Induced Hypertension: Relevant to Improvement of Renal and Intestinal Function.

Abstract Source:

J Agric Food Chem. 2022 Mar 30 ;70(12):3730-3744. Epub 2022 Mar 22. PMID: 35315647

Abstract Author(s):

Xiaoyuan Wang, Yueyue Liu, Yu Wang, Xinyue Dong, Youhua Wang, Xingbin Yang, Honglei Tian, Ting Li

Article Affiliation:

Xiaoyuan Wang

Abstract:

Hypertension has become a leading cardiovascular risk factor worldwide. In this study, we explored the salutary effects and relevant mechanisms of coriander (L.), an herbal plant with culinary and medicinal values, on high-fructose and high-salt diet (HFSD)-induced hypertension in SD rats. Our results showed that oral administration of coriander (1.0 or 2.0 g/kg·bw) effectively attenuated HFSD-induced elevation of systolic blood pressure, diastolic blood pressure, and mean arterial pressure. Coriander also increased the serum levels of vasodilator factors (PGI, NO, and eNOS), decreased Naretention and serum uric acid (UA) level, and ameliorated glucolipid profiles. qPCR results revealed that coriander downregulated the mRNA expression of NHE3, a Na/Hexchanger responsible for Naabsorption, in kidney and small intestine. 16S rDNA sequencing showed that coriander altered the gut microbiota composition with the beneficial bacteriaandsignificantly enriched. Correlation analysis indicated that the abundance ofwas evidently correlated with levels of NHE3, NO, eNOS, and UA. LC-MS/MS analysis revealed that coriander contained a variety of flavonoids including rutin and quercetin. Conclusively, long-term consumption of coriander may ameliorate HFSD-induced hypertension by mitigating HFSD-caused abnormal changes in vascular endothelial function, renal and intestinal sodium absorption, glucolipid homeostasis, and gut microbiota in rats.

Study Type : Animal Study

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