Abstract Title:

Long-term exposure to PMand stroke: A systematic review and meta-analysis of cohort studies.

Abstract Source:

Environ Res. 2019 Oct ;177:108587. Epub 2019 Jul 15. PMID: 31326714

Abstract Author(s):

Sheng Yuan, Jiaxin Wang, Qingqing Jiang, Ziyu He, Yuchai Huang, Zhengyang Li, Luyao Cai, Shiyi Cao

Article Affiliation:

Sheng Yuan


BACKGROUND: Stroke is one of the world's leading causes of death. Many studies have checked the relationship between short-term exposure to particulate matter (PM) and stroke, but few have focused on the effect of long-term exposure to PM(particulate matters with an aerodynamic diameter of≤2.5 μm). This study aimed to quantitatively examine the relationship of long-term exposure to PMwith stroke incidence and mortality.

METHODS: We identified relevant studies by searching the PubMed, EMBASE and MEDLINE. After the systematical review of pertinent studies, random-effect meta-analysis was conducted to investigate the association between long-term exposure to PMand stroke.

RESULTS: Our meta-analysis included 16 cohort studies with more than 2.2 million people and above 49 149 endpoint events (incident stroke and death from stroke). The pooled hazard ratio (HR) for each 5 μg/mincrement in PMwas 1.11 (95% CI: 1.05, 1.17) (CI for confidence interval) for incidence of stroke and 1.11 (95% CI:1.05, 1.17) for mortality of stroke. In the region-specific analysis, significant association between PMand incidence of stroke was found in North America (HR=1.09, 95% CI:1.05, 1.14) and Europe (HR=1.07, 95% CI:1.05, 1.10), while the pooled result of Asia showed no significance (HR=2.31, 95% CI:0.49, 10.95).

CONCLUSIONS: Long-term exposure to PMis an important risk factor for stroke. Since air quality is intimately related to everyone, policies aimed at reducing particulate matters will benefit public health a lot.

Study Type : Meta Analysis, Review

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