n/a
Abstract Title:

Long-term reproductive effects of benzo(a)pyrene at environmentally relevant dose on juvenile female rats.

Abstract Source:

Drug Chem Toxicol. 2022 Jul 31:1-9. Epub 2022 Jul 31. PMID: 35912572

Abstract Author(s):

Ana Carolina Casali Reis, Bárbara Campos Jorge, Beatriz Rizzo Paschoalini, Jéssica Nogueira Bueno, Julia Stein, Suyane da Silva Moreira, Beatriz de Manoel Manoel, Glaura Scantamburlo Alves Fernandes, Hamilton Hisano, Arielle Cristina Arena

Article Affiliation:

Ana Carolina Casali Reis

Abstract:

Since studies on the reproductive consequences after the exposure to environmentally relevant doses of Benzo(a)pyrene (BaP) during critical stages of development are scarce, this study evaluated female reproductive parameters of adult rats exposed to a low dose of BaP during the juvenile phase. Female rats (Post-natal 21) were treated with BaP (0 or 0.1 µg/kg/day; gavage) for 21 consecutive days. During the treatment, no clinical signs of toxicity were observed. Nevertheless, the ages of vaginal opening and first estrus were anticipated by the BaP-exposure. At the sexual maturity, the juvenile exposure compromised the sexual behavior, as well as the placental efficiency, follicle stimulating hormone levels, placenta histological analysis, and ovarian follicle count. A decrease in erythrocyte, platelet, and lymphocyte counts also was observed in the exposed-females. Moreover, the dose of BaP used in this study was not able to produce estrogenic activity. These data showed that juvenile BaP-exposure, at environmentally relevant dose, compromised the female reproductive system, possibly by an endocrine deregulation; however, this requires further investigation.

Study Type : Animal Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.