Article Publish Status: FREE
Abstract Title:

Long-term spontaneous regression of Stage IV diffuse large B-cell lymphoma.

Abstract Source:

J Clin Exp Hematop. 2021 Sep 10 ;61(3):168-172. Epub 2021 Jun 30. PMID: 34193754

Abstract Author(s):

Yoshiki Furukawa, Jun Ando, Miki Ando, Shintaro Kinoshita, Yoko Edahiro, Takuya Furuta, Koichi Ohshima, Norio Komatsu

Article Affiliation:

Yoshiki Furukawa


Diffuse large B cell lymphoma (DLBCL) is an aggressive disorder accounting for>30% of all lymphomas. Its prognosis is poor due to a high relapse rate. Spontaneous regression (SR) in DLBCL is rare, with only a few reported cases. Moreover, almost all of these were low-grade lymphomas with an average SR duration of 13 mo. As the cause of SR is unknown, there are many theories such as trauma, infection, medication, and an antitumor immune response. We present a patient with progressive DLBCL who demonstrated SR for>42 mo. Although treatment for lymphoma usually starts soon after diagnosis, insights into SR of lymphomas may lead to new treatment strategies.

Study Type : Human: Case Report

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