Abstract Title:

Rhabdomyolysis, acute renal failure and hepatopathy induced by lovastatin monotherapy.

Abstract Source:

Jpn Heart J. 1997 Jul ;38(4):541-5. PMID: 9350151

Abstract Author(s):

P H Chu, W J Chen, C W Chiang, Y S Lee

Article Affiliation:

Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan.


Lovastatin is a popular drug for the treatment of hypercholesterolemia. Few serious complications are associated with its use although rhabdomyolysis with renal failure has been reported when lovastatin is combined with cyclosporine or other drugs following transplantation. We report the case of a patient who developed hepatopathy and rhabdomyolysis accompanied by acute renal failure after 4 weeks of lovastatin monotherapy. The pathogenesis and treatment of these complications are also discussed.

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