Article Publish Status: FREE
Abstract Title:

LowAbundance in the Lower Gut Microbiota Is Associated With-Related Gastric Ulcer and Gastric Cancer.

Abstract Source:

Front Microbiol. 2021 ;12:631140. Epub 2021 Feb 26. PMID: 33717022

Abstract Author(s):

T Barani Devi, Krishnadas Devadas, Meekha George, A Gandhimathi, Deepak Chouhan, R J Retnakumar, Sneha Mary Alexander, Jijo Varghese, Sanjai Dharmaseelan, Sivakumar Krishnankutty Chandrika, V T Jissa, Bhabatosh Das, G Balakrish Nair, Santanu Chattopadhyay

Article Affiliation:

T Barani Devi


infection in stomach leads to gastric cancer, gastric ulcer, and duodenal ulcer. More than 1 million people die each year due to these diseases, but why most-infected individuals remain asymptomatic while a certain proportion develops such severe gastric diseases remained an enigma. Several studies indicated that gastric and intestinal microbiota may play a critical role in the development of the-associated diseases. However, no specific microbe in the gastric or intestinal microbiota has been clearly linked toinfection and related gastric diseases. Here, we studiedinfection, its virulence genes, the intestinal microbiota, and the clinical status of Trivandrum residents (= 375) in southwestern India by standardculture, PCR genotype, Sanger sequencing, and microbiome analyses using Illumina Miseq and Nanopore GridION. Our analyses revealed that gastric colonization by virulentstrains (+) is necessary but not sufficient for developing these diseases. Conversely, distinct microbial pools exist in the lower gut of the-infected vs.-non-infected individuals.(belonging to the phylum Actinobacteria) and(belonging to the phylum Bacteroidetes) were present in lower relative abundance for the+ group than the- group (<0.05). On the contrary, for the+ group, genus(bacteria belonging to the phylum Firmicutes) and genus(bacteria belonging to the phylum Bacteroidetes) were present in higher abundance compared to thegroup (<0.05). Notably, those who carriedin the stomach and had developed aggressive gastric diseases also had extremely low relative abundance (<0.05) of severalspecies (e.g.,,) in the lower gut suggesting a protective role of. Our results show the link between lower gastrointestinal microbes and upper gastrointestinal diseases. Moreover, the results are important for developing effective probiotic and early prognosis of severe gastric diseases.

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