Abstract Title:

Dual role of eugenol on chronic gastric ulcer in rats: Low-dose healing efficacy and the worsening gastric lesion in high doses.

Abstract Source:

Chem Biol Interact. 2020 Nov 24 ;333:109335. Epub 2020 Nov 24. PMID: 33245926

Abstract Author(s):

Bruna Longo, Ellen Perfoll Sommerfeld, Rita de Cássia Melo Vilhena de Andrade Fonseca da Silva, Lincon Bordignon Somensi, Luísa Nathalia Bolda Mariano, Thaise Boeing, Sérgio Faloni de Andrade, Priscila de Souza, Luísa Mota da Silva

Article Affiliation:

Bruna Longo


This study evaluated the gastric healing activity of eugenol, the main bioactive compound from clove (Syzygium aromaticun) essential oil. Five groups of female Wistar rats were submitted to acetic acid-induced ulcer model and treated with Vehicle (1 mL/kg, p.o.), eugenol (1, 10 or 100 mg/kg, p.o) or omeprazole (20 mg/kg, p.o), twice a day, by seven or fourteen days. Macroscopic, microscopic and biochemical analyses were performed in the ulcerated site. Eugenol (1 mg/kg, p.o) administered by 7 or 14 days accelerated the gastric healing process by 33% and 52%, respectively. The healing actions of eugenol were accompanied by the rescue on the histological architecture and the normalization of the superoxide dismutase and catalase activity. Moreover, eugenol (1 mg/kg, p.o) reduced the gastric mucosal myeloperoxidase activity and increased the mucin secretion. In contrast, eugenol at a dose of 100 mg/kg administered by 7 days enhanced 49% the ulcerated area, but at 10 mg/kg did not change the ulcer area after 7 or 14 days of treatment. Thus, despite the undesirable results due to the worsening of the gastric lesion with the use of eugenol in high doses, the antiulcer potential of this compound is evident and manageable in an adequate dose.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Gastroprotective : CK(955) : AC(388)

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