Article Publish Status: FREE
Abstract Title:

Low-level laser therapy enhances the number of osteocytes in calvaria bone defects of ovariectomized rats.

Abstract Source:

Animal Model Exp Med. 2019 Mar ;2(1):51-57. Epub 2019 Feb 21. PMID: 31016287

Abstract Author(s):

Priscilla Hakime Scalize, Luiz Gustavo de Sousa, Lígia Maria Napolitano Gonçalves, Dimitrius Leonardo Pitol, Marcelo Palinkas, Antônio Augusto Coppi, Mariah Acioli Righeti, Vitória Ricardo, Karina Fittipaldi Bombonato-Prado, Simone Cecílio Hallak Regalo, Selma Siessere

Article Affiliation:

Priscilla Hakime Scalize


Background: Osteoporosis can make bone repair difficult. Low-level laser therapy (LLLT) has been shown to be a promising tool for bone neoformation. This study aimed to analyze the effect of LLLT on calvaria bone defects of ovariectomized rats using stereology.

Methods: Fifty-four Wistar rats were subjected to bilateral ovariectomy, and bone defects were created in calvaria after 150 days. The animals were divided into nine groups (n =  6 per group), and 24 hours after the bone defects were created they received 3, 6 or 12 sessions of LLLT at 0, 20 or 30 J/cm, using a 780-nm low-intensity GaAlAs laser. One-way ANOVA followed by Tukey's post hoc test was used for data processing. A difference of < 0.05 was considered statistically significant. The parameters evaluated were osteocyte density (), total osteocyte number (), trabecular surface density (), and trabecular surface area ().

Results: Data obtained showed that,, andin group G2 rats were significantly different from G1 (0 J/cm) ( < 0.05). Compared to group G4, G5 presented higher values for the parametersand, and G6 presented significantly higher values for almost all the analyzed parameters (,,, and) ( < 0.05). Compared to group G7, G8 showed a higher value only for the parameter, and G9 showed significantly higher values for parameters,,, and.

Conclusion: We conclude that LLLT stimulated bone neoformation and contributed to an increase in the total number of osteocytes, especially with a laser energy density of 30 J/cmgiven for 6 and 12 sessions.

Study Type : Animal Study

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