Article Publish Status: FREE
Abstract Title:

Effect of Low-Level Laser Therapy in Treatment of Chemotherapy Induced Oral Mucositis.

Abstract Source:

J Lasers Med Sci. 2019 ;10(2):125-130. Epub 2019 Feb 25. PMID: 31360381

Abstract Author(s):

Soheir Shehata Rezk-Allah, Heba Mohamed Abd Elshaf, Reem Jan Farid, Mohamed Abd Elrahman Hassan, Samy A Alsirafy

Article Affiliation:

Soheir Shehata Rezk-Allah


Oral mucositis (OM) is an unavoidable condition of the oral cavity that accompanies chemotherapy for various malignant cases. Chemotherapy-induced oral Mucositis (COM) is a frequent complication due to mucotoxic drugs and is known to deteriorate the general health significantly, while negatively affecting the quality of life (QOL). Studies have reported that low-level laser therapy (LLLT) promotes the tissue healing. The objective of the present study was to explore the efficacy of gallium-arsenide (GaAs) laser in treating COM and its impact on inflammatory cytokine levels in patients receiving chemotherapy for various malignancies.A total of 80 patients with COM received LLLT 6 days/week. OM was graded according to the World Health Organization (WHO) grading scale. The outcome parameters were the serum levels of tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) measured before, during and after administration of LLLT.After LLLT, a significant decrease was found in the mean values of mucositis grade from 2.35± 0.695 to 1.13 ± 0.333 after (<0.001). A significant reduction in the level of TNF-α was found after LLLT among breast cancer patients (= 0.0045), but not in head and neck cancer and lymphoma patients. A significant reduction was also found in IL-6 level after treatment among head and neck and breast cancer patients (= 0.0307 and 0.019, respectively).The use of GaAs LLLT in treating COM in patients with various malignancies is well tolerated by patients, it results in improvement of mucositis, however; mechanism of action does not seem to be completely linked to the change of pro or anti-inflammatory cytokines.

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