Abstract Title:

The relationship between dietary magnesium intake, stroke and its major risk factors, blood pressure and cholesterol, in the EPIC-Norfolk cohort.

Abstract Source:

Int J Cardiol. 2015 Oct 1 ;196:108-14. Epub 2015 May 31. PMID: 26082204

Abstract Author(s):

Lucy K M Bain, Phyo K Myint, Amy Jennings, Marleen A H Lentjes, Robert N Luben, Kay-Tee Khaw, Nick J Wareham, Ailsa A Welch

Article Affiliation:

Lucy K M Bain


BACKGROUND: Dietary magnesium could modify the major stroke risk factors, high blood pressure (BP) and cholesterol, but has been understudied in both sexes in a single population. This study aimed to investigate if dietary magnesium intake was associated with BP, total cholesterol (TC) and incident stroke risk in an adult population.

METHODS: We conducted cross-sectional analyses in a case-cohort study of 4443, men and women aged 40-75, representative of 25,639 participants years of the EPIC (European Prospective Investigation into Cancer)-Norfolk cohort. The cohort included 928 stroke cases (42,556.5 person years). Dietary data from 7 day food diaries were analysed using multivariate regression to assess associations between quintiles or data-derived categories of dietary magnesium intake and BP, TC and stroke risk, adjusted for relevant confounders.

RESULTS: We observed differences of -7 mmHg systolic BP (P trend≤ 0.01) and -3.8 mmHg diastolic BP (P trend=0.01) between extreme intakes of magnesium in men, a significant inverse association with TC was observed (P trend=0.02 men and 0.04 women). Compared to the bottom 10%, the top 30% of magnesium intake was associated with a 41% relative reduction in stroke risk (HR 0.59; 95% CI 0.38-0.93) in men.

CONCLUSIONS: Lower dietary magnesium intake was associated with higher BP and stroke risk, which may have implications for primary prevention.

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