Abstract Title:

A Food-Derived Flavonoid Luteolin Protects against Angiotensin II-Induced Cardiac Remodeling.

Abstract Source:

PLoS One. 2015 ;10(9):e0137106. Epub 2015 Sep 1. PMID: 26327560

Abstract Author(s):

Atsuko Nakayama, Hiroyuki Morita, Tomoko Nakao, Toshihiro Yamaguchi, Tomokazu Sumida, Yuichi Ikeda, Hidetoshi Kumagai, Yoshihiro Motozawa, Tsukasa Takahashi, Atsushi Imaizumi, Tadashi Hashimoto, Ryozo Nagai, Issei Komuro

Article Affiliation:

Atsuko Nakayama


Oxidative stress has been implicated in cardiac remodeling (cardiac fibrosis and hypertrophy), which impairs cardiac function and metabolism; therefore, it is anticipated antioxidative compounds will have protective properties against cardiac remodeling. Luteolin (3',4',5,7-tetrahydroxyflavone), a widely distributed flavonoid found in many herbal extracts including celery, green pepper, perilla leaves and seeds, and chamomile, is a known to be a potent antioxidant and was previously demonstrated to exert an antifibrotic effect in the lungs and the liver. In this study, we clearly demonstrate that oral pretreatment with the higher-luteolin diet (0.035% (wt/wt)) protected against cardiac fibrosis and hypertrophy as well as a hyperoxidative state in Ang II-infused rats. In cardiac tissue, increased gene expression levels of TGFβ1, CTGF, Nox2, Nox4, ANP, and BNP induced by Ang II were restored by oral pretreatment of this high-luteolin diet. In cultured rat cardiac fibroblasts, H2O2-induced TGFβ1 expression and the phosphorylation of JNK were suppressed by luteolin pretreatment. In conclusion, food-derived luteolin has protective actions against Ang II-induced cardiac remodeling, which could be mediated through attenuation of oxidative stress.

Study Type : Human In Vitro

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