n/a
Article Publish Status: FREE
Abstract Title:

Effects ofPolysaccharide on Endoplasmic Reticulum Stress and Oxidative Stress in Obese Mice.

Abstract Source:

Front Pharmacol. 2020 ;11:742. Epub 2020 May 26. PMID: 32528287

Abstract Author(s):

Feng-Lian Yang, Yu-Xia Wei, Bi-Yun Liao, Gui-Jiang Wei, Hai-Mei Qin, Xiao-Xia Pang, Jun-Li Wang

Article Affiliation:

Feng-Lian Yang

Abstract:

Background: The incidence of obesity-associated decline in male fertility has increased over the years.polysaccharide (LBP), a natural plant polysaccharide extracted from the Chinese herbhas shown promising therapeutic effects in overcoming the same.

Aim: This study aimed to investigate the protective effect of LBP on the testes of obese mice.

Methods: Following administration of LBP to high-fat diet-induced obese mice for 35 days, serum, sperm, and testis samples were obtained for subsequent experiments. Biochemical analysis and sex hormone content determination were performed to observe changes in glycolipid metabolism and testosterone levels, respectively, in the blood. Hematoxylin and eosin staining were carried out to assess the pathological changes in the testicular tissue. Oxidative stress levels were detected using enzyme-linked immunosorbent assay and expression levels of endoplasmic reticulum stress markers were determined using western blot in the testicular tissue.

Results: Our results suggested that LBP reduced glucose levels and insulin resistance, increased testosterone levels and insulin sensitivity, and decreased testicular oxidative stress and pathological damage in obese mice. In addition, LBP down-regulated the expression of p-eIF2α, GRP78, and CHOP in the testicular tissues of obese mice.

Conclusion: Our results show that LBP is a potential novel drug for preventing male infertility caused by obesity.

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.