Polysaccharide Extracted fromLeaves Ameliorates Asthma in Mice by Reducing Inflammation and Modulating Gut Microbiota.
J Med Food. 2020 May 11. Epub 2020 May 11. PMID: 32392444
This study was designed to explore the impact ofpolysaccharide (LBP) on inflammation and gut microbiota in mice with allergic asthma. Mice were divided into four groups: control group, OVA (ovalbumin) group, Con+LBP group, OVA+LBP group. After 28 days of LBP intervention, mice were euthanized and associated indications were investigated. Histopathological examination demonstrated that LBP reduced lung injury. The results of our current study provide evidence that supplementation with LBP in asthmatic mice decreases,,,, andin plasma and bronchoalveolar lavage fluid (BALF). Sequencing and analysis of gut microbiota indicated that compared with the OVA group,andwere increased, but,,, andwere decreased in the OVA+LBP group. We also found that gut microbiota were related to inflammation-related factors. Therefore, we speculate that LBP may improve allergic asthma by altering gut microbiota and inhibiting inflammation in mice.