Abstract Title:

Role of EGFR/ErbB2 and PIK/AKT/e-NOS inAmeliorating Endothelial Dysfunction Induced by Oxidative Stress.

Abstract Source:

Am J Chin Med. 2019 Oct 23:1-17. Epub 2019 Oct 23. PMID: 31645123

Abstract Author(s):

Wenjuan Zhang, Huifang Yang, Lingqin Zhu, Yan Luo, Lihong Nie, Guanghua Li

Article Affiliation:

Wenjuan Zhang


(LBP) are the major ingredients of. In this study, we investigated the role of LBP in endothelial dysfunction induced by oxidative stress and the underlying mechanisms using thoracic aortic endothelial cells of rat (RAECs) as a model. We found that Ang II inhibits cell viability of RAECs with 10mol/L of Ang II treatment for 24h most potential (), the level of reactive oxygen species (ROS) is increased by Ang II treatment (), and the expression of Occludin and Zonula occludens-1 (ZO-1) is decreased by Ang II treatment (). However, preincubation of cells with LBP could inhibit the changes caused by Ang II, LBP increased cell viability (), decreased the level of ROS (), and up-regulated the expression of Occludin () and ZO-1. In addition, Ang II treatment increased the expression of EGFR and p-EGFR (Try1172) and which can be inhibited by LBP. On the contrary, expression of ErbB2, p-ErbB2 (Try1248), PIK, p-e-NOS (Ser1177) (), and p-AKT (Ser473) () was inhibited by Ang II treatment and which can be increased by LBP. Treatment of the cells with inhibitors showed that the regulation of p-e-NOS and p-AKT expression by Ang II and LBP can be blocked by PIK inhibitor wortmannin but not EGFR and ErbB2 inhibitor AC480. Taken together, our results suggested that LBP plays a critical role in maintaining the integrality of blood vessel endothelium through reduced production of ROS via regulating the activity of EGFR, ErbB2, PIK/AKT/e-NOS, and which may offer a novel therapeutic option in the management of endothelial dysfunction.

Study Type : In Vitro Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.