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Article Publish Status: FREE
Abstract Title:

Lycopene Inhibit IMQ-Induced Psoriasis-Like Inflammation by Inhibiting ICAM-1 Production in Mice.

Abstract Source:

Polymers (Basel). 2020 Jul 9 ;12(7). Epub 2020 Jul 9. PMID: 32659890

Abstract Author(s):

Chun-Ming Shih, Chi-Kun Hsieh, Chien-Yu Huang, Chun-Yao Huang, Kuo-Hsien Wang, Tsorng-Harn Fong, Nguyen Thi Thu Trang, Kuan-Ting Liu, Ai-Wei Lee

Article Affiliation:

Chun-Ming Shih

Abstract:

Lycopene is the most abundant carotenoid in tomatoes, which has been identified to have the properties of anti-inflammation in addition to the capability to inhibit the expression of adhesion molecules. Intercellular adhesion molecules play a critical role in the pathogenesis of psoriasis. Here, we report that the topical use of a lycopene decreased imiquimod (IMQ)-induced psoriasis-like inflammatory responses, the progress of which was based on adhesion molecules. In vitro analysis showed that lycopene decreased keratinocyte and monocyte adhesion. Evidence suggests that intercellular adhesion molecule-1 (ICAM-1) is a main mediator of psoriasis pathogenesis. Therefore, it will be interesting to investigate the factors that contribute to the lycopene-mediated inhibition of ICAM-1 expression in psoriasis. We expect that lycopene will with potential value in the treatment of psoriasis.

Study Type : In Vitro Study

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