Machilin A, a compound found within nutmeg, may have anabolic activity in bone metabolism. - GreenMedInfo Summary
Machilin A isolated from Myristica fragrans stimulates osteoblast differentiation.
Planta Med. 2009 Feb;75(2):152-7. Epub 2008 Dec 18. PMID: 19096999
This study evaluated the stimulatory effects of machilin A and structurally related lignans isolated from Myristica fragrans on osteoblast differentiation. In two IN VITRO osteoblast differentiation models, machilin A stimulated osteoblast differentiation via activation of p38 MAP kinase. Lignans isolated from Myristica fragrans also stimulated osteoblast differentiation in MC3T3-E1 cells; the lignans included macelignan, machilin F, nectandrin B, safrole, licarin A, licarin B, myristargenol, and meso-dihydroguaiaretic acid. These data suggest that lignans isolated from Myristica fragrans have anabolic activity in bone metabolism.