Abstract Title:

Machilin A isolated from Myristica fragrans stimulates osteoblast differentiation.

Abstract Source:

Planta Med. 2009 Feb;75(2):152-7. Epub 2008 Dec 18. PMID: 19096999

Abstract Author(s):

Su-Ui Lee, Ki Shuk Shim, Shi Yong Ryu, Yong Ki Min, Seong Hwan Kim


This study evaluated the stimulatory effects of machilin A and structurally related lignans isolated from Myristica fragrans on osteoblast differentiation. In two IN VITRO osteoblast differentiation models, machilin A stimulated osteoblast differentiation via activation of p38 MAP kinase. Lignans isolated from Myristica fragrans also stimulated osteoblast differentiation in MC3T3-E1 cells; the lignans included macelignan, machilin F, nectandrin B, safrole, licarin A, licarin B, myristargenol, and meso-dihydroguaiaretic acid. These data suggest that lignans isolated from Myristica fragrans have anabolic activity in bone metabolism.

Study Type : In Vitro Study
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