Article Publish Status: FREE
Abstract Title:

The effects of Malaysian propolis and Brazilian red propolis on connective tissue fibroblasts in the wound healing process.

Abstract Source:

BMC Complement Altern Med. 2015 ;15:294. Epub 2015 Aug 25. PMID: 26303848

Abstract Author(s):

Ann Jacob, Abhishek Parolia, Allan Pau, Fabian Davamani Amalraj

Article Affiliation:

Ann Jacob


BACKGROUND: To evaluate and compare the effects of ethanolic extracts of Malaysian propolis and Brazilian red propolis at different concentrations on the migration and proliferation of fibroblast cells.

METHODS: Malaysian and Brazilian red propolis crude samples were extracted using ethanol. Their wound healing effects were tested in vitro on the normal human fibroblast cell line CRL-7522. Cell migration and proliferation assays were carried out using propolis concentrations of 1, 10, 100, 250, 500 and 1000μg/mL. The data were analyzed using one-way ANOVA and post hoc Bonferroni tests (α=0.05).

RESULTS: Malaysian and Brazilian red propolis followed a concentration-dependent increasing and decreasing trend. Malaysian propolis showed the fastest migration rate at 250μg/mL which was statistically significant (p<0.05) and maximum proliferation at 500μg/mL with no significant difference (p>0.05) compared to control. Brazilian red propolis showed a slight increase in migration and proliferation at 10 and 100μg/mL, respectively with no significant difference (p>0.05) compared to control, while concentrations above these conferred inhibitory effects.

CONCLUSION: Malaysian and Brazilian red propolis show potential to assist in wound healing, depending on their concentration.

Study Type : Human In Vitro

Print Options

Key Research Topics

Sayer Ji
Founder of

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022, Journal Articles copyright of original owners, MeSH copyright NLM.