Article Publish Status: FREE
Abstract Title:

Cytoprotective Effects of Mangiferin and-Ligustilide in PAH-Exposed Human Airway Epithelium in Vitro.

Abstract Source:

Nutrients. 2019 Jan 22 ;11(2). Epub 2019 Jan 22. PMID: 30678167

Abstract Author(s):

Dovilė Grauzdytė, Jovilė Raudoniūtė, Ieva Kulvinskienė, Edvardas Bagdonas, Inga Stasiulaitienė, Dainius Martuzevičius, Daiva Bironaitė, Rūta Aldonytė, Petras Rimantas Venskutonis

Article Affiliation:

Dovilė Grauzdytė


According to World Health Organisation (WHO) air pollution increases the risk of cardiovascular disorders, respiratory diseases, including COPD, lung cancer and acute respiratory infections, neuro-degenerative and other diseases. It is also known that various phytochemicals may mitigate such risks. This study tested if phytochemicals mangiferin (MNG) and Z-ligustilide (Z-LG) may protect PAH-exposed human lung bronchial epithelial cells (BEAS-2B). Organic PAH extract was obtained from the urban fine PM with high benzo(a)pyrene content collected in Eastern European mid-sized city during winter heating season. Cell proliferation traits and levels of intracellular oxidative stress were examined. Effect of MNG (0.5µg/mL) alone or in combination with PAH on bronchial epithelium wound healing was evaluated. Both phytochemicals were also evaluated for their antioxidant properties in acellular system. Treatment with MNG produced strong cytoprotective effect on PAH-exposed cells (<0.01) while-LG (0.5µg/mL) exhibited strong negative effect on cell proliferation in untreated and PAH-exposed cells (<0.001). MNG, being many times stronger antioxidant than-LG in chemical in vitro assays (<0.0001), was also able to decrease PAH-induced oxidative stress in the cell cultures (<0.05). Consequently MNG ameliorates oxidative stress, speeds up wound healing process and restores proliferation rate in PAH-exposed bronchial epithelium. Such protective effects of MNG in air pollution affected airway epithelium stimulate further research on this promising phytochemical.

Study Type : In Vitro Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.