Abstract Title:

Antiviral effect of mangiferin and isomangiferin on herpes simplex virus.

Abstract Source:

Chin Med J (Engl). 1990 Feb;103(2):160-5. PMID: 2167819

Abstract Author(s):

M S Zheng, Z Y Lu

Article Affiliation:

Department of Microbiology, Jiangxi Medical College, Nanchang.


Using tissue culture technique the present study for the first time indicated the antiviral effect of mangiferin and isomangiferin against type I herpes simplex virus (HSV-I). 4 methods were used for evaluating drug effectiveness (i.e., in vitro drug-on-virus direct action, simultaneous addition of drug-virus-inoculum to cell bottle, virus inoculation preceding drug addition, and drug addition followed by virus inoculation), it was readily found by log determination of HSV-I inhibition that isomangiferin somewhat exceeded such control drugs as acyclovir, idoxuridine, and cyclocytidine in log by 0.27-0.50, and that mangiferin was lower than isomangiferin in log by 0.53. The average plaque reduction rates of mangiferin and isomangiferin were 56.8% and 69.5% respectively. The antiviral effect of mangiferin and isomangiferin was presumably due to their capability of inhibiting virus replication within cells.

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