Abstract Title:

Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines.

Abstract Source:

J Nat Prod. 2003 Aug;66(8):1124-7. PMID: 12932141

Abstract Author(s):

Kenji Matsumoto, Yukihiro Akao, Emi Kobayashi, Kenji Ohguchi, Tetsuro Ito, Toshiyuki Tanaka, Munekazu Iinuma, Yoshinori Nozawa


We examined the effects of six xanthones from the pericarps of mangosteen, Garcinia mangostana, on the cell growth inhibition of human leukemia cell line HL60. All xanthones displayed growth inhibitory effects. Among them, alpha-mangostin showed complete inhibition at 10 microM through the induction of apoptosis.

Study Type : In Vitro Study

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