Abstract Title:

Manuka Honey Induces Apoptosis of Epithelial Cancer Cells through Aquaporin-3 and Calcium Signaling.

Abstract Source:

Life (Basel). 2020 Oct 27 ;10(11). Epub 2020 Oct 27. PMID: 33120979

Abstract Author(s):

Simona Martinotti, Giorgia Pellavio, Mauro Patrone, Umberto Laforenza, Elia Ranzato

Article Affiliation:

Simona Martinotti


Honey is a natural product with a long use in traditional medicine and is well recognized to regulate different biological events. It is an important source of various biological or pharmacological molecules and, therefore, there is a strong interest to explore their properties. Evidence is growing that honey may have the potential to be an anticancer agent acting through several mechanisms. Here we observed for the first time in a cancer cell line a possible mechanism through which honey could induce an alteration in the intracellular reactive oxygen species and homeostatic balance of intracellular calcium concentration leading to cell death by apoptosis. This mechanism seems to be enhanced by manuka honey's ability to maintain high HOpermeability through aquaporin-3.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Apoptotic : CK(6986) : AC(5304)

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