Article Publish Status: FREE
Abstract Title:

Are Pediatric Antibiotic Formulations Potentials Risk Factors for Dental Caries and Dental Erosion?

Abstract Source:

Open Dent J. 2016 ;10:420-30. Epub 2016 Aug 22. PMID: 27583053

Abstract Author(s):

Ana Carolina Valinoti, Luiz Carlos da Costa, Adriana Farah, Valéria Pereira de Sousa, Andréa Fonseca-Gonçalves, Lucianne Cople Maia

Article Affiliation:

Ana Carolina Valinoti


INTRODUCTION: One of the most frequent parents' concerns is that oral antibiotic formulations induce dental damage in their children's. This study aimed to assess the cariogenic and erosive potentials of 29 pediatric antibiotics.

MATERIALS AND METHODS: Replicates of each antibiotic were analyzed for the concentration of sugars (sucrose, glucose and fructose) and sorbitol by high performance liquid chromatography (HPLC). The pH was determined by digital pHmeter. Titratable acidity was determined in triplicate using the same pHmeter by gradual addition of 0.1N sodium hydroxide (NaOH) until pH 7.0. Viscosity measurements were carried out using a viscosimeter. In order to rank the relative performance of each medicine, the DEA (Data Envelopment Analysis) methodology was used.

RESULTS: Sucrose was present in most samples (n=24) with concentrations ranging from 26 to≈ 100g% (w/w). Only one antibiotic contained sorbitol (66.9g%). Twenty seven antibiotics presented pH values ranging from 4.1 to 6.9 and most of them (n=15) showed the pH below the critical value for dissolution of hydroxyapatite. The values of titratable acidity and viscosity ranged from 0.26 to40.48 ml and from 20 to 1780cP, respectively. DEA methodology showed that two medicines were distant from the performance frontier (Klaricid(®) 50mg and Zinnat(®) 250mg), which means that these medicines showed the worst performance and, therefore, greater potential for dissolution of dental enamel.

CONCLUSION: Many antibiotics presented high concentration of sugars, high titratable acidity, pH below the critical value and high viscosity which can be considered risk factors for dental caries and erosion, when consumed frequently.

Study Type : In Vitro Study

Print Options

Key Research Topics

Sayer Ji
Founder of

Subscribe to our informative Newsletter & receive The Dark Side of Wheat Ebook

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

The Dark Side of Wheat

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2023, Journal Articles copyright of original owners, MeSH copyright NLM.