Maple syrup extract ingestion showed a dose-dependent pattern involved in energy metabolisms and reversely pattern involved in stress responses. - GreenMedInfo Summary

SCOPE: Maple syrup contains various polyphenols and we investigated the effects of a polyphenol-rich maple syrup extract (MSXH) on the physiology of mice fed a high-fat diet (HFD).

METHODS AND RESULTS: The mice fed a low-fat diet (LFD), an HFD, or an HFD supplemented with 0.02% (002MSXH) or 0.05% MSXH (005MSXH) for 4 weeks. Global gene expression analysis of the liver was performed, and the differentially expressed genes were classified into three expression patterns; pattern A (LFD002MSXH = 005MSXH, LFD>HFD<002MSXH = 005MSXH), pattern B (LFD005MSXH, LFD>HFD = 002MSXH<005MSXH), and pattern C (LFD002MSXH<005MSXH, LFD>HFD<002MSXH>005MSXH). Pattern A was enriched in glycolysis, fatty acid metabolism, and folate metabolism. Pattern B was enriched in tricarboxylic acid cycle while pattern C was enriched in gluconeogenesis, cholesterol metabolism, amino acid metabolism, and endoplasmic reticulum stress-related event.

CONCLUSION: Our study suggested that the effects of MSXH ingestion showed (i) dose-dependent pattern involved in energy metabolisms and (ii) reversely pattern involved in stress responses.