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Article Publish Status: FREE
Abstract Title:

Maternal obesity as a risk factor for developing diabetes in offspring: An epigenetic point of view.

Abstract Source:

World J Diabetes. 2021 Apr 15 ;12(4):366-382. PMID: 33889285

Abstract Author(s):

Simon Lecoutre, Salwan Maqdasy, Christophe Breton

Article Affiliation:

Simon Lecoutre

Abstract:

According to the developmental origin of health and disease concept, the risk of many age-related diseases is not only determined by genetic and adult lifestyle factors but also by factors acting during early development. In particular, maternal obesity and neonatal accelerated growth predispose offspring to overweight and type 2 diabetes (T2D) in adulthood. This concept mainly relies on the developmental plasticity of adipose tissue and pancreaticβ-cell programming in response to suboptimalduring the perinatal period. These changes result in unhealthy hypertrophic adipocytes with decreased capacity to store fat, low-grade inflammation and loss of insulin-producing pancreaticβ-cells. Over the past years, many efforts have been made to understand how maternal obesity induces long-lasting adipose tissue and pancreatic β-cell dysfunction in offspring and what are the molecular basis of the transgenerational inheritance of T2D. In particular, rodent studies have shed light on the role of epigenetic mechanisms in linking maternal nutritional manipulations to the risk for T2D in adulthood. In this review, we discuss epigenetic adipocyte and β-cell remodeling during development in the progeny of obese mothers and the persistence of these marks as a basis of obesity and T2D predisposition.

Study Type : Review

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