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Abstract Title:

[Matricaria chamomilla (aqueous extract) improves atopic dermatitis-like lesions in a murine model].

Abstract Source:

Rev Med Inst Mex Seguro Soc. 2017 Sep-Oct;55(5):587-593. PMID: 29193940

Abstract Author(s):

Raúl Julián Ortiz-Bautista, Laura Lucelly García-González, Marco Antonio Ocádiz-González, Julia Flores-Tochihuitl, Arturo García-Villaseñor, Margarita González-Hernández, Liliana Muñoz-Hernández, María del Consuelo Ortiz-Figueroa, Marisol Ramírez-Anaya, Silvia Reyna-Téllez, Octavio Villanueva-Sánchez

Article Affiliation:

Raúl Julián Ortiz-Bautista

Abstract:

BACKGROUND: Matricaria Chamomilla L. (Mch), popularly known as chamomile, has been used for centuries as an herbolary remedy due to its broad clinical spectrum. The aim of this study was to evaluate the effect of Mch associated to a vehicle with emollient function in induced atopic dermatitis (AD)-like lesions in a murine model.

METHODS: AD was induced with dinitrochlorobenzene on 12 male seven-week old BALB/c mice. Animals were divided in three groups (control, GC; control negative, GCN; and experimental, GE). Liquid petrolatum was applied to the GCN and liquid petrolatum with aqueous extract of Mch at 7% to the GE. Induction and evolution of the lesions were verified by biopsy at 2nd and 6th week. Evaluation of peripheral blood cells to correlate inflammatory cells was made as well at the same weeks. Lesions were clinically evaluated at 2nd, 4th and 6th week. Scratching was monitored according to the observation methodology of Kobayashi et al.

RESULTS: Mch aqueous extract associated to a vehicle with emollient function improves atopic dermatitis-like lesions after two weeks.

Study Type : Animal Study

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