n/a
Article Publish Status: FREE
Abstract Title:

Mechanisms of Macrophage Immunomodulatory Activity Induced by a New Polysaccharide Isolated From(Pers.) Fries.

Abstract Source:

Front Chem. 2020 ;8:581. Epub 2020 Jul 22. PMID: 32850623

Abstract Author(s):

Chun-Ping Liu, Xiong Li, Ge-Na Lai, Jin-Hua Li, Wen-Yu Jia, Ying-Ying Cao, Wen-Xing Xu, Qing-Long Tan, Chang-Yuan Zhou, Min Luo, Xue-Ying Zhang, Dao-Qing Yuan, Jin-Ying Tian, Xian Zhang, Xing Zeng

Article Affiliation:

Chun-Ping Liu

Abstract:

Bladder cancer is one of the most malignant tumors closely associated with macrophage immune dysfunction. The Chinese medicine polyporus has shown excellent efficacy in treating bladder cancer, with minimal side effects. However, its material basis and mechanism of action remain unclear. A new water-soluble polysaccharide (HPP) with strong immunomodulatory activity was isolated from the fungus(Pers.) Fries. HPP had an average molecular weight of 6.88 kDa and was composed mainly of an<-(1→ 4)-linked D-galactan backbone. The immunomodulatory activity of HPP was determined, and the results revealed that it could obviously increase the secretion of immune factors by IFN-γ-stimulated macrophages, including nitric oxide (NO), interleukin-6 (IL-6), interleukin-1β (IL-1β), RANTES and interleukin-23 (IL-23), and the expression of the cell membrane molecule CD80. In addition, HPP was recognized by Toll-like receptor 2 (TLR2) and activated the signaling pathways of NF-κB and NLRP3 in a bladder cancer microenvironment model, indicating that HPP could enhance host immune system function. These findings demonstrated that HPP may be a potential immune modulator in the treatment of immunological diseases or bladder cancer therapy.

Study Type : In Vitro Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.