Abstract Title:

Effectiveness of a treatment based on melatonin in five patients with systemic sclerosis.

Abstract Source:

Int J Mol Med. 2010 Nov;26(5):673-8. PMID: 16428927

Abstract Author(s):

Mauro Todisco


Systemic sclerosis (SSc) is a multisystem connective disorder in which endothelial damage leads to fibrotic reactions through platelet hyperaggregability and inappropriate release of platelet-derived growth factors. With other colleagues, I have previously reported that melatonin seems to have a direct favorable effect on endothelium (stopping of bleeding symptoms in thrombocytopenic patients). Furthermore, melatonin has been described as performing an antiaggregating activity, and ACTH and vitamin E have been described as increasing melatonin effects. This provided the rationale to treat 5 SSc patients with melatonin plus ACTH and vitamin E. Patients received the treatment for 1 month. The therapy was continued for 2 additional months in patients with stable or responding disease. After 3 months, the stable or responding patients continued the therapy for 2 months and longer. All patients had a partial response after 1 month. Continuing with the treatment, none of the 5 patients had disease progression (average follow-up time of 16.6 months; range, 7-44 months). Toxicity was lacking, with the only side effect being drowsiness. Our experience suggests that the combination of melatonin-ACTH-vitamin E may be safe and effective in patients with SSc.

Study Type : Human Study

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