Abstract Title:

The antioxidative property of melatonin against brain ischemia.

Abstract Source:

Expert Rev Neurother. 2016 May 9:1-8. Epub 2016 May 9. PMID: 27108742

Abstract Author(s):

Irene Paterniti, Marika Cordaro, Emanuela Esposito, Salvatore Cuzzocrea

Article Affiliation:

Irene Paterniti


This review briefly summarizes some of the large amount of data documenting the ability of melatonin to limit molecular and organ tissue damage in neural ischemia-reperfusion injury (stroke), where free radicals are generally considered as being responsible for much of the resulting tissue destruction. Area Covered: Melatonin actions that have been identified include its ability to directly neutralize a number of toxic reactants and stimulate antioxidative enzymes. Furthermore, several of its metabolites such as N(1)-acetyl-N(2)-formyl-5- methoxykynuramine (AFMK) and N(1)-acetyl-5-methoxykynuramine (AMF), are themselves scavengers suggesting that there is a cascade of reactions that greatly increase the efficacy of melatonin. Expert Commentary: However, the mechanisms by which melatonin is protective in such widely diverse areas of the cell and different organs are likely not yet all identified.

Study Type : Review

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Sayer Ji
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