Abstract Title:

Protective and sensitive effects of melatonin combined with adriamycin on ER+ (estrogen receptor) breast cancer.

Abstract Source:

Eur J Gynaecol Oncol. 2015 ;36(2):197-202. PMID: 26050360

Abstract Author(s):

C Ma, L X Li, Y Zhang, C Xiang, T Ma, Z Q Ma, Z P Zhang

Article Affiliation:

C Ma


OBJECTIVE: This study aims to investigate the protective and sensitive effects of melatonin (MLT) in the treatment of breast cancer.

MATERIALS AND METHODS: ER+ breast cancer rat model was established and then rats were randomly divided into five different groups as follows: control group, Diss group, adriamycin (ADM) group, MLT group, and MLT combined with adriamycin (M+A) group. Tumor weights and one month survival rate were compared among these groups. In addition, changes of tumor tissues and expression of E-cadherin were observed under optical microscopy or electro-microscopy.

RESULTS: Tumor weights were significantly lighter in M+A group than those in ADM group (p<0.05). Under optical and electro-microscopy, tumor cell apoptosis was obviously increased in MLT group, and tumor cell injury was more severe in M+A group than that in ADM group; additionally, expression of E-cadherin was higher in MLT group and M+A group than that in other groups. Moreover, MLT group had the highest one month survival rate (100%), there was the poorest life quality in ADM group, but the best life quality in MLT.

CONCLUSION: MLT could enhance the sensitivity of tumor to ADM in vivo and improve patient's life quality.

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Sayer Ji
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