Abstract Title:

Melatonin ingestion after exhaustive late-evening exercise attenuate muscle damage, oxidative stress, and inflammation during intense short term effort in the following day in teenage athletes.

Abstract Source:

Chronobiol Int. 2019 Dec 2:1-12. Epub 2019 Dec 2. PMID: 31790604

Abstract Author(s):

Mohamed Cheikh, Khouloud Makhlouf, Kais Ghattassi, Ahmed Graja, Salyma Ferchichi, Choumous Kallel, Mallek Houda, Nizar Souissi, Omar Hammouda

Article Affiliation:

Mohamed Cheikh


The present study aimed to investigate whether nocturnal melatonin (MEL) ingestion has beneficial effects against exercise-induced oxidative stress and muscle damage in young athletes. Fourteen healthy-trained teenagers performed two-test sessions separated by at least, 1 week. During each session, participants completed the Running-Based Anaerobic Sprint Test (RAST) at 20:00 h. Then, they ingested a single 10-mg tablet of MEL or Placebo (PLA) in a double-blind randomized order at 22:00 h. The following morning (i.e., 07:30 h), participants performed the same test as the previous night. Blood samples were taken before and after exercise. MEL intake increased the peak power (P) (<.01), mean power (P) (<.001) and decreased the total time (TT) (<.001) and the fatigue index (FI) (<.05). Furthermore, MEL ingestion attenuated the hematologic parameters before and after exercise (White Blood Cells (WBC:<.001 and<.001, respectively); Neutrophiles (NE:<.001 and<.001, respectively); Lymphocytes (LY:<.001 and<.001, respectively)) and the ultra-sensitive C-reactive protein (us-CRP:<.001 and<.001; respectively) compared to PLA. Also, MEL reduced muscle and hepatic damage enzymes before and after exercise (creatine kinase (CK:<.001 and<.001; respectively), lactate dehydrogenase (LDH:<.05 and<.01; respectively), aspartate aminotransferase (ASAT:<.01 and<.001; respectively)),(MDA:<.001 and<.001; respectively) and Homocysteine (Hcy:<.001 and<.001; respectively)) from placebo. Plasma lactate [La] and glucose (GL) remained unchangeable during the two conditions. In summary, acute MEL ingestion after strenuous late-evening exercise attenuated transient leucocytosis and protected against lipid peroxidation and muscle damage induced by strenuous exercise the following morning in healthy male teenage athletes.

Study Type : Human Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.