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Article Publish Status: FREE
Abstract Title:

The membrane effects of melittin on gastric and colorectal cancer.

Abstract Source:

PLoS One. 2019 ;14(10):e0224028. Epub 2019 Oct 17. PMID: 31622415

Abstract Author(s):

Caroline Soliman, Sarah Eastwood, Vi Khanh Truong, Paul A Ramsland, Aaron Elbourne

Article Affiliation:

Caroline Soliman

Abstract:

The cytotoxic effects of melittin, a bee-venom peptide, have been widely studied towards cancer cells. Typically, these studies have examined the effect of melittin over extended-time courses (6-24 hours), meaning that immediate cellular interactions have been overlooked. In this work, we demonstrate the rapid effects of melittin on both gastric and colorectal cancer, specifically AGS, COLO205 and HCT-15 cell lines, over a period of 15 minutes. Melittin exhibited a dose dependent effect at 4 hours of treatment, with complete cellular death occurring at the highest dose of 20μg/mL. Interestingly, when observed at shorter time points, melittin induced cellular changes within seconds; membrane damage was observed as swelling, breakage or blebbing. High-resolution imaging revealed treated cells to be compromised, showing clear change in cellular morphology. After 1 minuteof melittin treatment, membrane changes were observed, and intracellular material could be seen expelled from the cells. Overall, these results enhance our understanding of the fast acting anti-cancer effects of melittin.

Study Type : In Vitro Study

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