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Abstract Title:

Metabolic effects of L-citrulline in type 2 diabetes.

Abstract Source:

Acta Physiol (Oxf). 2023 Jan 16:e13937. Epub 2023 Jan 16. PMID: 36645144

Abstract Author(s):

Fatemeh Bagheripour, Sajad Jeddi, Khosrow Kashfi, Asghar Ghasemi

Article Affiliation:

Fatemeh Bagheripour

Abstract:

The prevalence of type 2 diabetes (T2D) is increasing worldwide. Decreased nitric oxide (NO) bioavailability is involved in the pathophysiology of T2D and its complications. L-citrulline (Cit), a precursor of NO production, has been suggested as a novel therapeutic agent for T2D. Available data from human and animal studies indicate that Cit supplementation in T2D increases circulating levels of Cit and L-arginine while decreasing circulating glucose and free fatty acids and improving dyslipidemia. The underlying mechanisms for these beneficial effects of Cit include increased insulin secretion from the pancreaticβcells, increased glucose uptake by the skeletal muscle, as well as increased lipolysis andβ-oxidation, and decreased glyceroneogenesis in the adipose tissue. Thus, Cit has antihyperglycemic, antidyslipidemic, and antioxidant effects and has the potential to be used as a new therapeutic agent in the management of T2D. This review summarizes available literature from human and animal studies to explore the effects of Cit on metabolic parameters in T2D. It also discusses the possible mechanisms underlying Cit-induced improved metabolic parameters in T2D.

Study Type : Review

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